Corus CAD is the only blood test that can help clinicians quickly, accurately, and safely assess whether or not their patients’ chest discomfort or other symptoms may be due to obstructive coronary artery disease (CAD). The Corus CAD test is a decision-making tool that can help identify patients unlikely to have obstructive CAD* as the cause of the patient’s symptoms and help clinicians determine appropriate next steps for patient management.

Corus CAD:

• Has been clinically validated in two prospective, multi-center studies in the U.S. called PREDICT and COMPASS.^1,2 Read the highlights.
• Provides an assessment of your likelihood of obstructive CAD without risks associated with imaging radiation, imaging agents, or contrast solutions
• Integrates age, sex, and gene expression to calculate a score, which has been demonstrated to accurately assess the likelihood of obstructive CAD²
• Is the first sex-specific test for obstructive CAD that accounts for cardiovascular differences between men and women
• Demonstrated high sensitivity (89%) and high negative predictive value (96%) at a score threshold ≤15 in the COMPASS study population of men and women²
• Can be performed through a quick, routine blood draw conveniently administered right in your office
• Delivers objective, reproducible results within a few days
• Complements and improves the current noninvasive assessment of suspected obstructive CAD

Who is the Corus CAD patient?

The Corus CAD test is intended for use in patients who present with stable symptoms suggestive of obstructive CAD.

Typical symptoms suggestive of CAD may include:

• Chest discomfort, tightness, pain, or pressure
• Shortness of breath

Atypical symptoms suggestive of CAD may include:

• • Tightness or pressure in the throat, jaw, shoulder, abdomen, back, or arm
  • Squeezing, heaviness, or burning sensation in the upper body
  • Abdominal discomfort or fullness
  • Indigestion or heartburn
  • Nausea
  • Vomiting
  • Dizziness or light-headedness
  • Palpitations or awareness of heartbeat

The Corus CAD test is NOT intended for patients who:

• Have a history of obstructive CAD
• Have had a prior myocardial infarction or revascularization procedure
• Are diabetic
• Are currently taking steroids, immuno-suppressive agents, or chemotherapeutic agents

What is gene expression?

Gene expression is the term used to describe gene activity, or production of RNA (ribonucleic acid), in response to environmental factors. Gene expression occurs throughout a person’s life in all cells and tissues. Gene expression can change in response to disease and other conditions. Some tests incorporate gene expression to help clinicians assess a patient’s disease status. Gene expression reflects what’s happening in a patient’s body right now.

What does Corus CAD measure?

The Corus CAD algorithm integrates age, sex, and gene expression to calculate a score. Combining the Corus CAD score with other patient information provides clinicians with a more complete picture of their patient’s CAD status through the test’s clinical validity in identifying patients unlikely to have obstructive CAD.